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Rushing & Receiving
| No. | | Age | Pos | G | GS | Att | Yds | TD | Lng | Y/A | Y/G | A/G | Rec | Yds | Y/R | TD | Lng | R/G | Y/G | YScm | RRTD | Fmb |
|---|
| 21 | Frank Gore* | 28 | RB | 16 | 15 | 282 | 1211 | 8 | 55 | 4.3 | 75.7 | 17.6 | 17 | 114 | 6.7 | 0 | 13 | 1.1 | 7.1 | 1325 | 8 | 2 |
| 32 | Kendall Hunter | 23 | rb | 16 | 1 | 112 | 473 | 2 | 44 | 4.2 | 29.6 | 7.0 | 16 | 195 | 12.2 | 0 | 44 | 1.0 | 12.2 | 668 | 2 | 1 |
| 11 | Alex Smith | 27 | QB | 16 | 16 | 52 | 179 | 2 | 14 | 3.4 | 11.2 | 3.3 | | | | | | | | 179 | 2 | 7 |
| 24 | Anthony Dixon | 24 | | 16 | 0 | 29 | 87 | 2 | 9 | 3.0 | 5.4 | 1.8 | 1 | 6 | 6.0 | 0 | 6 | 0.1 | 0.4 | 93 | 2 | 0 |
| 19 | Ted Ginn Jr. | 26 | wr | 14 | 3 | 8 | 68 | 0 | 24 | 8.5 | 4.9 | 0.6 | 19 | 220 | 11.6 | 0 | 26 | 1.4 | 15.7 | 288 | 0 | 0 |
| 49 | Bruce Miller | 24 | fb | 15 | 8 | 4 | 8 | 0 | 3 | 2.0 | 0.5 | 0.3 | 11 | 83 | 7.5 | 1 | 30 | 0.7 | 5.5 | 91 | 1 | 1 |
| 46 | Delanie Walker | 27 | fb/te | 15 | 7 | 3 | 5 | 0 | 14 | 1.7 | 0.3 | 0.2 | 19 | 198 | 10.4 | 3 | 29 | 1.3 | 13.2 | 203 | 3 | 1 |
| 85 | Vernon Davis | 27 | TE | 16 | 16 | 2 | -5 | 0 | -2 | -2.5 | -0.3 | 0.1 | 67 | 792 | 11.8 | 6 | 44 | 4.2 | 49.5 | 787 | 6 | 3 |
| 10 | Kyle Williams | 23 | wr | 13 | 1 | 2 | 32 | 0 | 25 | 16.0 | 2.5 | 0.2 | 20 | 241 | 12.1 | 3 | 56 | 1.5 | 18.5 | 273 | 3 | 2 |
| 7 | Colin Kaepernick | 24 | | 3 | 0 | 2 | -2 | 0 | -1 | -1.0 | -0.7 | 0.7 | | | | | | | | -2 | 0 | 0 |
| 15 | Michael Crabtree | 24 | WR | 15 | 14 | 1 | 6 | 0 | 6 | 6.0 | 0.4 | 0.1 | 72 | 874 | 12.1 | 4 | 52 | 4.8 | 58.3 | 880 | 4 | 0 |
| 4 | Andy Lee*+ | 29 | p | 16 | 0 | 1 | -18 | 0 | -18 | -18.0 | -1.1 | 0.1 | | | | | | | | -18 | 0 | 0 |
| 17 | Braylon Edwards | 28 | wr | 9 | 5 | 0 | 0 | 0 | 0 | | 0.0 | 0.0 | 15 | 181 | 12.1 | 0 | 24 | 1.7 | 20.1 | 181 | 0 | 0 |
| 84 | Josh Morgan | 26 | wr | 5 | 5 | 0 | 0 | 0 | 0 | | 0.0 | 0.0 | 15 | 220 | 14.7 | 1 | 30 | 3.0 | 44.0 | 220 | 1 | 0 |
| 18 | Brett Swain | 26 | wr | 5 | 1 | 0 | 0 | 0 | 0 | | 0.0 | 0.0 | 2 | 15 | 7.5 | 0 | 9 | 0.4 | 3.0 | 15 | 0 | 0 |
| 81 | Justin Peelle | 32 | te/wr | 14 | 2 | 0 | 0 | 0 | 0 | | 0.0 | 0.0 | 1 | 19 | 19.0 | 0 | 19 | 0.1 | 1.4 | 19 | 0 | 0 |
| 90 | Isaac Sopoaga | 30 | DL/nt | 15 | 15 | 0 | 0 | 0 | 0 | | 0.0 | 0.0 | 1 | 18 | 18.0 | 0 | 18 | 0.1 | 1.2 | 18 | 0 | 0 |
| 74 | Joe Staley* | 27 | LT/t | 16 | 16 | 0 | 0 | 0 | 0 | | 0.0 | 0.0 | 1 | 17 | 17.0 | 0 | 17 | 0.1 | 1.1 | 17 | 0 | 0 |
| Team Total | 26.0 | | 16 | | 498 | 2044 | 14 | 55 | 4.1 | 127.8 | 31.1 | 277 | 3193 | 11.5 | 18 | 56 | 17.3 | 199.6 | 5237 | 32 | 18 |
| Opp Total | | | 16 | | 353 | 1236 | 3 | | 3.5 | 77.3 | 22.1 | 333 | 3695 | 11.1 | 20 | | 20.8 | 230.9 | 4931 | 23 | 31 |