| 98 | Antwan Barnes | 27 | lb | 16 | 5 | 240 | 6-1 | Florida International | 10/19/1984 | 4 | 3 | Baltimore Ravens / 4th / 134th pick / 2007 |
| 60 | Colin Baxter | 24 | | 5 | 0 | 310 | 6-3 | Arizona | 7/31/1987 | Rook | 0 | |
| 97 | Bront Bird | 22 | | 9 | 0 | 250 | 6-4 | Texas Tech | 3/17/1989 | Rook | 1 | |
| 44 | Curtis Brinkley | 26 | | 10 | 1 | 208 | 5-9 | Syracuse | 9/20/1985 | 1 | 1 | |
| 91 | Everette Brown | 24 | | 3 | 0 | 250 | 6-4 | Florida St. | 8/7/1987 | 2 | 0 | Carolina Panthers / 2nd / 43rd pick / 2009 |
| 86 | Vincent Brown | 22 | wr | 14 | 4 | 187 | 5-11 | San Diego St. | 1/25/1989 | Rook | 3 | San Diego Chargers / 3rd / 82nd pick / 2011 |
| 51 | Donald Butler | 23 | LB | 16 | 16 | 248 | 6-1 | Central Washington | 10/17/1988 | Rook | 7 | San Diego Chargers / 3rd / 79th pick / 2010 |
| 20 | Antoine Cason | 25 | CB | 16 | 14 | 190 | 6-0 | Arizona | 7/9/1986 | 3 | 5 | San Diego Chargers / 1st / 27th pick / 2008 |
| 93 | Luis Castillo | 28 | de | 1 | 1 | 306 | 6-3 | Northwestern | 8/4/1983 | 6 | 0 | San Diego Chargers / 1st / 28th pick / 2005 |
| 74 | Jacques Cesaire | 31 | de | 12 | 2 | 295 | 6-2 | Southern Connecticut St. | 8/30/1980 | 8 | 1 | |
| 66 | Jeromey Clary | 28 | RT | 16 | 16 | 304 | 6-6 | Kansas St. | 11/5/1983 | 4 | 9 | San Diego Chargers / 6th / 187th pick / 2006 |
| 54 | Stephen Cooper | 32 | | 5 | 0 | 235 | 6-1 | Maine | 6/19/1979 | 8 | 0 | |
| 12 | Patrick Crayton | 32 | wr | 14 | 1 | 205 | 6-0 | NW Oklahoma St. | 4/7/1979 | 7 | 3 | Dallas Cowboys / 7th / 216th pick / 2004 |
| 68 | Kris Dielman | 30 | g | 6 | 6 | 310 | 6-4 | Indiana | 2/3/1981 | 8 | 3 | |
| 58 | Na'il Diggs | 33 | | 13 | 0 | 238 | 6-4 | Ohio St. | 7/8/1978 | 11 | 1 | Green Bay Packers / 4th / 98th pick / 2000 |
| 62 | Brandyn Dombrowski | 26 | c | 15 | 2 | 323 | 6-5 | San Diego St. | 4/3/1985 | 2 | 2 | |
| 52 | Larry English | 25 | | 5 | 0 | 254 | 6-2 | Northern Illinois | 1/22/1986 | 2 | 0 | San Diego Chargers / 1st / 16th pick / 2009 |
| 80 | Malcom Floyd | 30 | WR | 12 | 9 | 201 | 6-5 | Wyoming | 9/8/1981 | 7 | 9 | |
| 59 | Andrew Gachkar | 23 | | 16 | 0 | 228 | 6-3 | Missouri | 11/4/1988 | Rook | 1 | San Diego Chargers / 7th / 234th pick / 2011 |
| 78 | Jared Gaither | 25 | lt | 5 | 5 | 350 | 6-9 | Maryland | 3/18/1986 | 4 | 3 | Baltimore Ravens / 5th / 2007 Supp |
| 49 | Darryl Gamble | 24 | | 5 | 0 | 255 | 6-2 | Georgia | 11/17/1987 | Rook | 0 | |
| 71 | Antonio Garay | 32 | DT | 16 | 13 | 300 | 6-4 | Boston Col. | 11/30/1979 | 8 | 5 | Cleveland Browns / 6th / 195th pick / 2003 |
| 85 | Antonio Gates* | 31 | TE | 13 | 13 | 260 | 6-4 | Kent St. | 6/18/1980 | 8 | 10 | |
| 38 | Marcus Gilchrist | 23 | cb | 14 | 4 | 195 | 5-10 | Clemson | 12/8/1988 | Rook | 2 | San Diego Chargers / 2nd / 50th pick / 2011 |
| 15 | Richard Goodman | 24 | | 16 | 0 | 192 | 6-0 | Florida State | 4/30/1987 | 1 | 1 | |
| 69 | Tyronne Green | 25 | C | 13 | 8 | 305 | 6-1 | Auburn | 4/6/1986 | 2 | 4 | San Diego Chargers / 4th / 133rd pick / 2009 |
| 28 | Steve Gregory | 28 | SS | 15 | 13 | 185 | 5-11 | Syracuse | 1/8/1983 | 5 | 5 | |
| 61 | Nick Hardwick | 30 | C | 16 | 16 | 295 | 6-4 | Purdue | 9/12/1981 | 7 | 8 | San Diego Chargers / 3rd / 66th pick / 2004 |
| 90 | Tommie Harris | 28 | de | 13 | 1 | 300 | 6-3 | Oklahoma | 4/29/1983 | 7 | 1 | Chicago Bears / 1st / 14th pick / 2004 |
| 22 | Jacob Hester | 26 | fb | 16 | 3 | 230 | 5-11 | LSU | 5/8/1985 | 3 | 3 | San Diego Chargers / 3rd / 69th pick / 2008 |
| 33 | Dante Hughes | 26 | cb | 16 | 1 | 190 | 5-10 | California | 8/21/1985 | 4 | 1 | Indianapolis Colts / 3rd / 95th pick / 2007 |
| 83 | Vincent Jackson* | 28 | WR | 16 | 16 | 241 | 6-5 | Northern Colorado | 1/14/1983 | 6 | 12 | San Diego Chargers / 2nd / 61st pick / 2005 |
| 23 | Quentin Jammer | 32 | CB | 15 | 15 | 204 | 6-0 | Texas | 6/19/1979 | 9 | 5 | San Diego Chargers / 1st / 5th pick / 2002 |
| 10 | Nate Kaeding | 29 | | 1 | 0 | 187 | 6-0 | Iowa | 3/26/1982 | 7 | 0 | San Diego Chargers / 3rd / 65th pick / 2004 |
| 99 | Travis LaBoy | 30 | LB | 14 | 14 | 249 | 6-4 | Utah St.,Hawaii | 8/10/1981 | 7 | 5 | Tennessee Titans / 2nd / 42nd pick / 2004 |
| 94 | Corey Liuget | 21 | DT | 15 | 13 | 298 | 6-2 | East. Illinois | 3/18/1990 | Rook | 5 | San Diego Chargers / 1st / 18th pick / 2011 |
| 92 | Vaughn Martin | 25 | DE | 16 | 15 | 331 | 6-3 | West. Ontario | 4/18/1986 | 2 | 6 | San Diego Chargers / 4th / 113th pick / 2009 |
| 24 | Ryan Mathews* | 24 | RB | 14 | 14 | 220 | 6-0 | Fresno St. | 5/1/1987 | 1 | 14 | San Diego Chargers / 1st / 12th pick / 2010 |
| 81 | Randy McMichael | 32 | TE | 16 | 14 | 250 | 6-3 | Georgia | 6/28/1979 | 9 | 5 | Miami Dolphins / 4th / 114th pick / 2002 |
| 73 | Marcus McNeill | 28 | LT | 9 | 9 | 335 | 6-8 | Auburn | 11/16/1983 | 5 | 4 | San Diego Chargers / 2nd / 50th pick / 2006 |
| 75 | Tony Moll | 28 | g | 3 | 1 | 285 | 6-4 | Nevada-Reno | 8/23/1983 | 5 | 1 | Green Bay Packers / 5th / 165th pick / 2006 |
| 63 | Scott Mruczkowski | 29 | c | 10 | 1 | 321 | 6-4 | Bowling Green | 4/5/1982 | 6 | 1 | San Diego Chargers / 7th / 242nd pick / 2005 |
| 60 | Ikechuku Ndukwe | 29 | | 2 | 0 | 338 | 6-4 | Northwestern | 7/17/1982 | 5 | 0 | |
| 9 | Nick Novak | 30 | | 15 | 0 | 191 | 6-0 | Maryland | 8/21/1981 | 6 | 0 | |
| 91 | Ogemdi Nwagbuo | 26 | | 4 | 0 | 300 | 6-4 | Michigan St. | 12/24/1985 | 2 | 0 | |
| 27 | Paul Oliver | 27 | s | 13 | 1 | 208 | 6-0 | Georgia | 3/30/1984 | 3 | 1 | |
| 95 | Shaun Phillips | 30 | LB | 12 | 12 | 260 | 6-3 | Purdue | 5/13/1981 | 7 | 5 | San Diego Chargers / 4th / 98th pick / 2004 |
| 17 | Philip Rivers* | 30 | QB | 16 | 16 | 228 | 6-5 | North Carolina St. | 12/8/1981 | 7 | 17 | New York Giants / 1st / 4th pick / 2004 |
| 31 | Bob Sanders | 30 | ss | 2 | 2 | 200 | 5-8 | Iowa | 2/24/1981 | 7 | 1 | Indianapolis Colts / 2nd / 44th pick / 2004 |
| 70 | Stephen Schilling | 23 | lg | 9 | 2 | 308 | 6-4 | Central Michigan | 7/21/1988 | Rook | 2 | San Diego Chargers / 6th / 201st pick / 2011 |
| 5 | Mike Scifres | 31 | | 16 | 0 | 236 | 6-2 | West. Illinois | 10/8/1980 | 8 | 0 | San Diego Chargers / 5th / 149th pick / 2003 |
| 82 | Kory Sperry | 26 | te | 16 | 4 | 242 | 6-4 | Colorado St. | 4/10/1985 | 2 | 2 | |
| 51 | Takeo Spikes | 35 | LB | 16 | 16 | 242 | 6-2 | Auburn | 12/17/1976 | 13 | 6 | Cincinnati Bengals / 1st / 13th pick / 1998 |
| 25 | Darrell Stuckey | 24 | | 14 | 0 | 205 | 5-11 | Arkansas | 6/16/1987 | 1 | 1 | San Diego Chargers / 4th / 110th pick / 2010 |
| 76 | Cam Thomas | 23 | dt | 16 | 2 | 330 | 6-3 | North Carolina | 12/12/1988 | 1 | 2 | San Diego Chargers / 5th / 146th pick / 2010 |
| 35 | Mike Tolbert | 26 | fb | 15 | 1 | 243 | 5-9 | Coastal Carolina | 11/23/1985 | 3 | 10 | |
| 65 | Louis Vasquez | 24 | G | 14 | 14 | 330 | 6-4 | Texas Tech | 4/11/1987 | 2 | 7 | San Diego Chargers / 3rd / 78th pick / 2009 |
| 7 | Billy Volek | 35 | | 2 | 0 | 214 | 6-2 | Fresno St. | 4/28/1976 | 10 | 0 | |
| 26 | C.J. Wallace | 26 | | 1 | 0 | 218 | 6-0 | Washington | 4/17/1985 | 4 | 0 | |
| 13 | Bryan Walters | 24 | | 4 | 0 | 190 | 6-0 | Cornell | 11/4/1987 | Rook | 0 | |
| 32 | Eric Weddle*+ | 26 | FS | 16 | 16 | 203 | 5-11 | Utah | 1/4/1985 | 4 | 12 | San Diego Chargers / 2nd / 37th pick / 2007 |
| 47 | Mike Windt | 25 | | 16 | 0 | 251 | 6-1 | Cincinnati | 5/29/1986 | 1 | 0 | |
| 29 | Shareece Wright | 24 | | 7 | 0 | 185 | 5-11 | USC | 4/8/1987 | Rook | 0 | San Diego Chargers / 3rd / 89th pick / 2011 |