| | Offensive Starters | | | | |
| QB | Ben Roethlisberger | 24 | 2 | 15 | 280 for 469, 3,513 yards, 18 td, 23 int, & 32 rushes for 98 yards and 2 td | Pittsburgh Steelers / 1st / 11th pick / 2004 |
| RB | Willie Parker* | 26 | 2 | 16 | 337 rushes for 1,494 yards, 13 td, & 31 catches for 222 yards and 3 td | |
| FB | Dan Kreider | 29 | 6 | 12 | 1 rush for 5 yards, 0 td, & 8 catches for 62 yards and 0 td | |
| WR | Hines Ward | 30 | 8 | 14 | 74 catches for 975 yards, 6 td, & 2 rushes for 30 yards and 0 td | Pittsburgh Steelers / 3rd / 92nd pick / 1998 |
| WR | Cedrick Wilson | 28 | 5 | 12 | 37 catches for 504 yards, 1 td, & 2 rushes for 14 yards and 0 td | San Francisco 49ers / 6th / 169th pick / 2001 |
| TE | Heath Miller | 24 | 1 | 16 | 34 catches for 393 yards, 5 td | Pittsburgh Steelers / 1st / 30th pick / 2005 |
| LT | Marvel Smith | 28 | 6 | 16 | 1 fumble recovered | Pittsburgh Steelers / 2nd / 38th pick / 2000 |
| LG | Alan Faneca*+ | 30 | 8 | 16 | 2 fumbles recovered | Pittsburgh Steelers / 1st / 26th pick / 1998 |
| C | Jeff Hartings | 34 | 10 | 14 | 1 fumble recovered | Detroit Lions / 1st / 23rd pick / 1996 |
| RG | Kendall Simmons | 27 | 4 | 14 | | Pittsburgh Steelers / 1st / 30th pick / 2002 |
| RT | Max Starks | 24 | 2 | 14 | | Pittsburgh Steelers / 3rd / 75th pick / 2004 |
| | Defensive Starters | | | | |
| LDE | Aaron Smith | 30 | 7 | 16 | 4.5 sacks, 0 interceptions, 1 fumble recovered | Pittsburgh Steelers / 4th / 109th pick / 1999 |
| NT | Casey Hampton* | 29 | 5 | 15 | | Pittsburgh Steelers / 1st / 19th pick / 2001 |
| RDE | Brett Keisel | 28 | 4 | 16 | 5.5 sacks, 0 interceptions, 1 fumble recovered | Pittsburgh Steelers / 7th / 242nd pick / 2002 |
| LOLB | Clark Haggans | 29 | 6 | 15 | 6.0 sacks, 1 interception, 1 fumble recovered | Pittsburgh Steelers / 5th / 137th pick / 2000 |
| LILB | James Farrior | 31 | 9 | 16 | 4.0 sacks, 1 interception, 1 fumble recovered | New York Jets / 1st / 8th pick / 1997 |
| RILB | Larry Foote | 26 | 4 | 16 | 4.0 sacks, 1 interception, 1 fumble recovered | Pittsburgh Steelers / 4th / 128th pick / 2002 |
| ROLB | Joey Porter | 29 | 7 | 14 | 7.0 sacks, 2 interceptions, 0 fumbles recovered | Pittsburgh Steelers / 3rd / 73rd pick / 1999 |
| LCB | Ike Taylor | 26 | 3 | 11 | 0.0 sacks, 2 interceptions, 1 fumble recovered | Pittsburgh Steelers / 4th / 125th pick / 2003 |
| RCB | Deshea Townsend | 31 | 8 | 12 | 2.0 sacks, 2 interceptions, 0 fumbles recovered | Pittsburgh Steelers / 4th / 117th pick / 1998 |
| SS | Troy Polamalu* | 25 | 3 | 13 | 1.0 sacks, 3 interceptions, 0 fumbles recovered | Pittsburgh Steelers / 1st / 16th pick / 2003 |
| FS | Ryan Clark | 27 | 4 | 12 | 0.0 sacks, 1 interception, 3 fumbles recovered | |
| | Special Teams Starters | | | | |
| K | Jeff Reed | 27 | 4 | 0 | 20 of 27 field goals & 41 of 41 extra points | |
| P | Chris Gardocki | 36 | 15 | 0 | 65 punts for a 41.3 average, 0 blocked | Chicago Bears / 3rd / 78th pick / 1991 |
| PR | Santonio Holmes | 22 | Rook | 4 | 26 punt returns for a 10.2 average and 1 td | Pittsburgh Steelers / 1st / 25th pick / 2006 |
| KR | Najeh Davenport | 27 | 4 | 0 | 21 kick returns for a 21.3 average and 0 td | Green Bay Packers / 4th / 135th pick / 2002 |