| 1. | Flipper Anderson | 336 | Los Angeles Rams vs. New Orleans Saints, November 26, 1989 |
| 2. | Billy Cannon | 330 | Houston Oilers vs. New York Titans, December 10, 1961 |
| 3. | Keith Lincoln | 329 | San Diego Chargers vs. Boston Patriots, January 5, 1964 |
| 4. | Adrian Peterson (22) | 315 | Minnesota Vikings vs. San Diego Chargers, November 4, 2007 |
| 5. | Stephone Paige | 309 | Kansas City Chiefs vs. San Diego Chargers, December 22, 1985 |
| 6. | Priest Holmes | 307 | Kansas City Chiefs vs. Seattle Seahawks, November 24, 2002 |
| 7. | Jerry Rice+ | 299 | San Francisco 49ers vs. Minnesota Vikings, December 18, 1995 |
| 8. | Jerome Harrison | 298 | Cleveland Browns vs. Kansas City Chiefs, December 20, 2009 |
| 9. | Jamal Lewis | 295 | Baltimore Ravens vs. Cleveland Browns, September 14, 2003 |
| 10. | Herschel Walker | 292 | Dallas Cowboys vs. Philadelphia Eagles, December 14, 1986 |
| 11. | Jimmy Smith | 291 | Jacksonville Jaguars vs. Baltimore Ravens, September 10, 2000 |
| 12. | Jim Brown+ | 289 | Cleveland Browns vs. Philadelphia Eagles, November 19, 1961 |
| 13. | Jamaal Charles (26) | 288 | Kansas City Chiefs vs. New Orleans Saints, September 23, 2012 |
| Terrell Owens | 288 | San Francisco 49ers vs. Chicago Bears, December 17, 2000 |
| 15. | John Taylor | 286 | San Francisco 49ers vs. Los Angeles Rams, December 11, 1989 |
| Marshall Faulk+ | 286 | St. Louis Rams vs. Atlanta Falcons, October 15, 2000 |
| 17. | Chris Johnson (24) | 284 | Tennessee Titans vs. Houston Texans, September 20, 2009 |
| 18. | Walter Payton+ | 281 | Chicago Bears vs. Minnesota Vikings, November 20, 1977 |
| 19. | Delvin Williams | 279 | San Francisco 49ers vs. Washington Redskins, November 7, 1976 |
| 20. | Corey Dillon | 278 | Cincinnati Bengals vs. Denver Broncos, October 22, 2000 |
| 21. | Priest Holmes | 277 | Kansas City Chiefs vs. Oakland Raiders, December 9, 2001 |
| 22. | Tiki Barber | 276 | New York Giants vs. Philadelphia Eagles, December 28, 2002 |
| Corey Dillon | 276 | Cincinnati Bengals vs. Tennessee Oilers, December 4, 1997 |
| 24. | O.J. Simpson+ | 273 | Buffalo Bills vs. Detroit Lions, November 25, 1976 |
| Andre Johnson (31) | 273 | Houston Texans vs. Jacksonville Jaguars, November 18, 2012 |
| Shaun Alexander | 273 | Seattle Seahawks vs. Oakland Raiders, November 11, 2001 |
| 27. | Charley Hennigan | 272 | Houston Oilers vs. Boston Patriots, October 13, 1961 |
| Doug Martin (23) | 272 | Tampa Bay Buccaneers vs. Oakland Raiders, November 4, 2012 |
| 29. | LaDainian Tomlinson | 271 | San Diego Chargers vs. Denver Broncos, December 1, 2002 |
| 30. | Del Shofner | 269 | New York Giants vs. Washington Redskins, October 28, 1962 |
| 31. | Thurman Thomas+ | 268 | Buffalo Bills vs. Miami Dolphins, September 1, 1991 |
| 32. | Jerry Butler | 267 | Buffalo Bills vs. New York Jets, September 23, 1979 |
| Marshall Faulk+ | 267 | Indianapolis Colts vs. Baltimore Ravens, November 29, 1998 |
| 34. | Chuck Foreman | 265 | Minnesota Vikings vs. Philadelphia Eagles, October 24, 1976 |
| Lee Evans | 265 | Buffalo Bills vs. Houston Texans, November 19, 2006 |
| 36. | James Brooks | 264 | Cincinnati Bengals vs. New England Patriots, December 7, 1986 |
| 37. | Tiki Barber | 263 | New York Giants vs. Oakland Raiders, December 31, 2005 |
| 38. | Duce Staley | 262 | Philadelphia Eagles vs. Dallas Cowboys, September 3, 2000 |
| Jamaal Charles (23) | 262 | Kansas City Chiefs vs. Denver Broncos, January 3, 2010 |
| Jim Brown+ | 262 | Cleveland Browns vs. Washington Redskins, September 15, 1963 |
| 41. | Steve Largent+ | 261 | Seattle Seahawks vs. Detroit Lions, October 18, 1987 |
| Marshall Faulk+ | 261 | St. Louis Rams vs. New Orleans Saints, December 24, 2000 |
| 43. | LaDainian Tomlinson | 260 | San Diego Chargers vs. Oakland Raiders, December 28, 2003 |
| Wes Chandler | 260 | San Diego Chargers vs. Cincinnati Bengals, December 20, 1982 |
| Chad Johnson | 260 | Cincinnati Bengals vs. San Diego Chargers, November 12, 2006 |
| 46. | Qadry Ismail | 258 | Baltimore Ravens vs. Pittsburgh Steelers, December 12, 1999 |
| Marshall Faulk+ | 258 | St. Louis Rams vs. Chicago Bears, December 26, 1999 |
| Tiki Barber | 258 | New York Giants vs. Washington Redskins, December 30, 2006 |
| 49. | Anthony Carter | 257 | Minnesota Vikings vs. San Francisco 49ers, January 9, 1988 |
| 50. | Darrin Nelson | 256 | Minnesota Vikings vs. Green Bay Packers, November 13, 1983 |
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