| 1. | Gale Sayers+ | 36 | Chicago Bears vs. San Francisco 49ers, December 12, 1965 |
| 2. | Paul Hornung+ | 33 | Green Bay Packers vs. Baltimore Colts, October 8, 1961 |
| 3. | Ricky Watters | 30 | San Francisco 49ers vs. New York Giants, January 15, 1994 |
| Kellen Winslow+ | 30 | San Diego Chargers vs. Oakland Raiders, November 22, 1981 |
| Paul Hornung+ | 30 | Green Bay Packers vs. Baltimore Colts, December 12, 1965 |
| Shaun Alexander | 30 | Seattle Seahawks vs. Minnesota Vikings, September 29, 2002 |
| Cookie Gilchrist | 30 | Buffalo Bills vs. New York Jets, December 8, 1963 |
| Billy Cannon | 30 | Houston Oilers vs. New York Titans, December 10, 1961 |
| Abner Haynes | 30 | Dallas Texans vs. Oakland Raiders, November 26, 1961 |
| James Stewart | 30 | Jacksonville Jaguars vs. Philadelphia Eagles, October 12, 1997 |
| Clinton Portis | 30 | Denver Broncos vs. Kansas City Chiefs, December 7, 2003 |
| Jerry Rice+ | 30 | San Francisco 49ers vs. Atlanta Falcons, October 14, 1990 |
| 13. | Paul Hornung+ | 28 | Green Bay Packers vs. Minnesota Vikings, September 16, 1962 |
| Gino Cappelletti | 28 | Boston Patriots vs. Houston Oilers, December 18, 1965 |
| 15. | George Blanda+ | 26 | Houston Oilers vs. Los Angeles Chargers, September 18, 1960 |
| Rob Bironas (29) | 26 | Tennessee Titans vs. Houston Texans, October 21, 2007 |
| 17. | Jay Feely (34) | 25 | Arizona Cardinals vs. Denver Broncos, December 12, 2010 |
| 18. | Doug Martin (23) | 24 | Tampa Bay Buccaneers vs. Oakland Raiders, November 4, 2012 |
| LaDainian Tomlinson | 24 | San Diego Chargers vs. Denver Broncos, November 19, 2006 |
| Emmitt Smith+ | 24 | Dallas Cowboys vs. New York Giants, September 4, 1995 |
| Dick James | 24 | Washington Redskins vs. Dallas Cowboys, December 17, 1961 |
| Rodney Hampton | 24 | New York Giants vs. New Orleans Saints, September 24, 1995 |
| Wilbert Montgomery | 24 | Philadelphia Eagles vs. Washington Redskins, October 7, 1979 |
| LaDainian Tomlinson | 24 | San Diego Chargers vs. Oakland Raiders, October 14, 2007 |
| Mike Anderson | 24 | Denver Broncos vs. New Orleans Saints, December 3, 2000 |
| Jerry Butler | 24 | Buffalo Bills vs. New York Jets, September 23, 1979 |
| Chuck Muncie | 24 | San Diego Chargers vs. Denver Broncos, November 29, 1981 |
| LaDainian Tomlinson | 24 | San Diego Chargers vs. Cincinnati Bengals, November 12, 2006 |
| Jimmie Giles | 24 | Tampa Bay Buccaneers vs. Miami Dolphins, October 20, 1985 |
| Joseph Addai | 24 | Indianapolis Colts vs. Philadelphia Eagles, November 26, 2006 |
| Roy Green | 24 | St. Louis Cardinals vs. Seattle Seahawks, November 13, 1983 |
| Emmitt Smith+ | 24 | Dallas Cowboys vs. Phoenix Cardinals, December 16, 1990 |
| Jim Taylor+ | 24 | Green Bay Packers vs. Chicago Bears, November 4, 1962 |
| Wilbert Montgomery | 24 | Philadelphia Eagles vs. Washington Redskins, September 10, 1978 |
| Larry Brown | 24 | Washington Redskins vs. Philadelphia Eagles, December 16, 1973 |
| Roland Hooks | 24 | Buffalo Bills vs. Cincinnati Bengals, September 9, 1979 |
| Barry Sanders+ | 24 | Detroit Lions vs. Minnesota Vikings, November 24, 1991 |
| Jim Brown+ | 24 | Cleveland Browns vs. Philadelphia Eagles, November 19, 1961 |
| Steven Jackson (23) | 24 | St. Louis Rams vs. Minnesota Vikings, December 31, 2006 |
| T.J. Duckett | 24 | Atlanta Falcons vs. Oakland Raiders, December 12, 2004 |
| Corey Dillon | 24 | Cincinnati Bengals vs. Tennessee Oilers, December 4, 1997 |
| Jim Brown+ | 24 | Cleveland Browns vs. Pittsburgh Steelers, November 28, 1965 |
| Isaac Bruce | 24 | St. Louis Rams vs. San Francisco 49ers, October 10, 1999 |
| Wayne Morris | 24 | St. Louis Cardinals vs. New Orleans Saints, October 23, 1977 |
| Marshall Faulk+ | 24 | St. Louis Rams vs. Indianapolis Colts, December 30, 2001 |
| Art Powell | 24 | Oakland Raiders vs. Houston Oilers, December 22, 1963 |
| Michael Turner (26) | 24 | Atlanta Falcons vs. Carolina Panthers, November 23, 2008 |
| Darren McFadden (23) | 24 | Oakland Raiders vs. Denver Broncos, October 24, 2010 |
| Priest Holmes | 24 | Kansas City Chiefs vs. Cleveland Browns, September 8, 2002 |
| Marshall Faulk+ | 24 | St. Louis Rams vs. Minnesota Vikings, December 10, 2000 |
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