| 1. | Adrian Peterson (22) | 296 | Minnesota Vikings vs. San Diego Chargers, November 4, 2007 |
| 2. | Jamal Lewis | 295 | Baltimore Ravens vs. Cleveland Browns, September 14, 2003 |
| 3. | Jerome Harrison | 286 | Cleveland Browns vs. Kansas City Chiefs, December 20, 2009 |
| 4. | Corey Dillon | 278 | Cincinnati Bengals vs. Denver Broncos, October 22, 2000 |
| 5. | Walter Payton+ | 275 | Chicago Bears vs. Minnesota Vikings, November 20, 1977 |
| 6. | O.J. Simpson+ | 273 | Buffalo Bills vs. Detroit Lions, November 25, 1976 |
| 7. | Shaun Alexander | 266 | Seattle Seahawks vs. Oakland Raiders, November 11, 2001 |
| 8. | Jamaal Charles (23) | 259 | Kansas City Chiefs vs. Denver Broncos, January 3, 2010 |
| 9. | DeMarco Murray (23) | 253 | Dallas Cowboys vs. St. Louis Rams, October 23, 2011 |
| 10. | Mike Anderson | 251 | Denver Broncos vs. New Orleans Saints, December 3, 2000 |
| Doug Martin (23) | 251 | Tampa Bay Buccaneers vs. Oakland Raiders, November 4, 2012 |
| 12. | O.J. Simpson+ | 250 | Buffalo Bills vs. New England Patriots, September 16, 1973 |
| Spec Sanders | 250 | New York Yankees vs. Chicago Rockets, October 24, 1947 |
| 14. | Eric Dickerson+ | 248 | Los Angeles Rams vs. Dallas Cowboys, January 4, 1986 |
| 15. | Willie Ellison | 247 | Los Angeles Rams vs. New Orleans Saints, December 5, 1971 |
| 16. | Corey Dillon | 246 | Cincinnati Bengals vs. Tennessee Oilers, December 4, 1997 |
| 17. | Cookie Gilchrist | 243 | Buffalo Bills vs. New York Jets, December 8, 1963 |
| LaDainian Tomlinson | 243 | San Diego Chargers vs. Oakland Raiders, December 28, 2003 |
| 19. | Jim Brown+ | 237 | Cleveland Browns vs. Philadelphia Eagles, November 19, 1961 |
| Jim Brown+ | 237 | Cleveland Browns vs. Los Angeles Rams, November 24, 1957 |
| Barry Sanders+ | 237 | Detroit Lions vs. Tampa Bay Buccaneers, November 13, 1994 |
| Emmitt Smith+ | 237 | Dallas Cowboys vs. Philadelphia Eagles, October 31, 1993 |
| 23. | Fred Taylor | 234 | Jacksonville Jaguars vs. Pittsburgh Steelers, November 19, 2000 |
| Tiki Barber | 234 | New York Giants vs. Washington Redskins, December 30, 2006 |
| 25. | Jamaal Charles (26) | 233 | Kansas City Chiefs vs. New Orleans Saints, September 23, 2012 |
| 26. | Jim Brown+ | 232 | Cleveland Browns vs. Dallas Cowboys, September 22, 1963 |
| Bobby Mitchell+ | 232 | Cleveland Browns vs. Washington Redskins, November 15, 1959 |
| 28. | Arian Foster (24) | 231 | Houston Texans vs. Indianapolis Colts, September 12, 2010 |
| 29. | Ricky Williams | 228 | Miami Dolphins vs. Buffalo Bills, December 1, 2002 |
| Clinton Portis | 228 | Denver Broncos vs. Arizona Cardinals, December 29, 2002 |
| Chris Wells (23) | 228 | Arizona Cardinals vs. St. Louis Rams, November 27, 2011 |
| Chris Johnson (24) | 228 | Tennessee Titans vs. Jacksonville Jaguars, November 1, 2009 |
| 33. | Napoleon Kaufman | 227 | Oakland Raiders vs. Denver Broncos, October 19, 1997 |
| Priest Holmes | 227 | Baltimore Ravens vs. Cincinnati Bengals, November 22, 1998 |
| O.J. Simpson+ | 227 | Buffalo Bills vs. Pittsburgh Steelers, September 28, 1975 |
| 36. | Jamaal Charles (26) | 226 | Kansas City Chiefs vs. Indianapolis Colts, December 23, 2012 |
| 37. | Adrian Peterson (22) | 224 | Minnesota Vikings vs. Chicago Bears, October 14, 2007 |
| 38. | Willie Parker | 223 | Pittsburgh Steelers vs. Cleveland Browns, December 7, 2006 |
| Jim Brown+ | 223 | Cleveland Browns vs. Philadelphia Eagles, November 3, 1963 |
| Tommy Wilson | 223 | Los Angeles Rams vs. Green Bay Packers, December 16, 1956 |
| 41. | Greg Bell | 221 | Los Angeles Rams vs. Green Bay Packers, September 24, 1989 |
| Bo Jackson | 221 | Los Angeles Raiders vs. Seattle Seahawks, November 30, 1987 |
| Gerald Riggs | 221 | Washington Redskins vs. Philadelphia Eagles, September 17, 1989 |
| 44. | Michael Turner (26) | 220 | Atlanta Falcons vs. Detroit Lions, September 7, 2008 |
| Tiki Barber | 220 | New York Giants vs. Kansas City Chiefs, December 17, 2005 |
| LaDainian Tomlinson | 220 | San Diego Chargers vs. Denver Broncos, December 1, 2002 |
| Marshall Faulk+ | 220 | St. Louis Rams vs. New Orleans Saints, December 24, 2000 |
| Barry Sanders+ | 220 | Detroit Lions vs. Minnesota Vikings, November 24, 1991 |
| 49. | O.J. Simpson+ | 219 | Buffalo Bills vs. New England Patriots, December 9, 1973 |
| Edgerrin James | 219 | Indianapolis Colts vs. Seattle Seahawks, October 15, 2000 |
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