| 1. | Ricky Watters | 5 | San Francisco 49ers vs. New York Giants, January 15, 1994 |
| Jim Brown+ | 5 | Cleveland Browns vs. Baltimore Colts, November 1, 1959 |
| Clinton Portis | 5 | Denver Broncos vs. Kansas City Chiefs, December 7, 2003 |
| Cookie Gilchrist | 5 | Buffalo Bills vs. New York Jets, December 8, 1963 |
| James Stewart | 5 | Jacksonville Jaguars vs. Philadelphia Eagles, October 12, 1997 |
| 6. | Bobby Douglass | 4 | Chicago Bears vs. Green Bay Packers, November 4, 1973 |
| Dorsey Levens | 4 | Green Bay Packers vs. Arizona Cardinals, January 2, 2000 |
| Wayne Morris | 4 | St. Louis Cardinals vs. New Orleans Saints, October 23, 1977 |
| Shaun Alexander | 4 | Seattle Seahawks vs. Houston Texans, October 16, 2005 |
| Lorenzo White | 4 | Houston Oilers vs. Cleveland Browns, December 9, 1990 |
| Priest Holmes | 4 | Kansas City Chiefs vs. Atlanta Falcons, October 24, 2004 |
| Jim Brown+ | 4 | Cleveland Browns vs. Chicago Cardinals, October 26, 1958 |
| Terdell Middleton | 4 | Green Bay Packers vs. Seattle Seahawks, October 15, 1978 |
| Ronald Moore | 4 | Phoenix Cardinals vs. Los Angeles Rams, December 5, 1993 |
| Corey Dillon | 4 | Cincinnati Bengals vs. Tennessee Oilers, December 4, 1997 |
| Emmitt Smith+ | 4 | Dallas Cowboys vs. Phoenix Cardinals, December 16, 1990 |
| Doug Martin (23) | 4 | Tampa Bay Buccaneers vs. Oakland Raiders, November 4, 2012 |
| Dub Jones | 4 | Cleveland Browns vs. Chicago Bears, November 25, 1951 |
| Derrick Blaylock | 4 | Kansas City Chiefs vs. Atlanta Falcons, October 24, 2004 |
| Earl Campbell+ | 4 | Houston Oilers vs. Miami Dolphins, November 20, 1978 |
| Michael Turner (26) | 4 | Atlanta Falcons vs. Carolina Panthers, November 23, 2008 |
| DeAngelo Williams (25) | 4 | Carolina Panthers vs. New York Giants, December 21, 2008 |
| Jim Brown+ | 4 | Cleveland Browns vs. Philadelphia Eagles, November 19, 1961 |
| Curt Warner | 4 | Seattle Seahawks vs. Denver Broncos, December 11, 1988 |
| Jim Taylor+ | 4 | Green Bay Packers vs. Chicago Bears, November 4, 1962 |
| Jim Brown+ | 4 | Cleveland Browns vs. St. Louis Cardinals, November 18, 1962 |
| Jamal Lewis | 4 | Cleveland Browns vs. Seattle Seahawks, November 4, 2007 |
| Barry Sanders+ | 4 | Detroit Lions vs. Minnesota Vikings, November 24, 1991 |
| Shaun Alexander | 4 | Seattle Seahawks vs. Minnesota Vikings, September 29, 2002 |
| LaDainian Tomlinson | 4 | San Diego Chargers vs. Cincinnati Bengals, November 12, 2006 |
| Billy Kilmer | 4 | San Francisco 49ers vs. Minnesota Vikings, October 15, 1961 |
| Mike Anderson | 4 | Denver Broncos vs. New Orleans Saints, December 3, 2000 |
| Jim Taylor+ | 4 | Green Bay Packers vs. Philadelphia Eagles, November 11, 1962 |
| Priest Holmes | 4 | Kansas City Chiefs vs. Cleveland Browns, September 8, 2002 |
| Shaun Alexander | 4 | Seattle Seahawks vs. Arizona Cardinals, September 25, 2005 |
| Leroy Kelly+ | 4 | Cleveland Browns vs. New York Giants, December 1, 1968 |
| Calvin Hill | 4 | Dallas Cowboys vs. Buffalo Bills, September 19, 1971 |
| Ronnie Brown (27) | 4 | Miami Dolphins vs. New England Patriots, September 21, 2008 |
| Clarence Williams | 4 | San Diego Chargers vs. Buffalo Bills, September 16, 1979 |
| Emmitt Smith+ | 4 | Dallas Cowboys vs. New York Giants, September 4, 1995 |
| LaDainian Tomlinson | 4 | San Diego Chargers vs. Oakland Raiders, October 14, 2007 |
| Marshall Faulk+ | 4 | St. Louis Rams vs. Minnesota Vikings, December 10, 2000 |
| Abner Haynes | 4 | Dallas Texans vs. Oakland Raiders, November 26, 1961 |
| Gale Sayers+ | 4 | Chicago Bears vs. San Francisco 49ers, December 12, 1965 |
| DeAngelo Williams (25) | 4 | Carolina Panthers vs. Green Bay Packers, November 30, 2008 |
| Jim Taylor+ | 4 | Green Bay Packers vs. Cleveland Browns, October 15, 1961 |
| Willis McGahee (23) | 4 | Buffalo Bills vs. Seattle Seahawks, November 28, 2004 |
| Eric Dickerson+ | 4 | Indianapolis Colts vs. Denver Broncos, October 31, 1988 |
| T.J. Duckett | 4 | Atlanta Falcons vs. Oakland Raiders, December 12, 2004 |
| Rodney Hampton | 4 | New York Giants vs. New Orleans Saints, September 24, 1995 |
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