| 1. | Kellen Winslow+ | 5 | San Diego Chargers vs. Oakland Raiders, November 22, 1981 |
| Abner Haynes | 5 | Dallas Texans vs. Oakland Raiders, November 26, 1961 |
| Billy Cannon | 5 | Houston Oilers vs. New York Titans, December 10, 1961 |
| Gale Sayers+ | 5 | Chicago Bears vs. San Francisco 49ers, December 12, 1965 |
| Shaun Alexander | 5 | Seattle Seahawks vs. Minnesota Vikings, September 29, 2002 |
| James Stewart | 5 | Jacksonville Jaguars vs. Philadelphia Eagles, October 12, 1997 |
| Ricky Watters | 5 | San Francisco 49ers vs. New York Giants, January 15, 1994 |
| Cookie Gilchrist | 5 | Buffalo Bills vs. New York Jets, December 8, 1963 |
| Jerry Rice+ | 5 | San Francisco 49ers vs. Atlanta Falcons, October 14, 1990 |
| Clinton Portis | 5 | Denver Broncos vs. Kansas City Chiefs, December 7, 2003 |
| Paul Hornung+ | 5 | Green Bay Packers vs. Baltimore Colts, December 12, 1965 |
| 12. | Doug Martin (23) | 4 | Tampa Bay Buccaneers vs. Oakland Raiders, November 4, 2012 |
| Ronald Moore | 4 | Phoenix Cardinals vs. Los Angeles Rams, December 5, 1993 |
| Roy Green | 4 | St. Louis Cardinals vs. Seattle Seahawks, November 13, 1983 |
| Jim Brown+ | 4 | Cleveland Browns vs. St. Louis Cardinals, November 18, 1962 |
| Wayne Morris | 4 | St. Louis Cardinals vs. New Orleans Saints, October 23, 1977 |
| Curt Warner | 4 | Seattle Seahawks vs. Denver Broncos, December 11, 1988 |
| Ronnie Brown (27) | 4 | Miami Dolphins vs. New England Patriots, September 21, 2008 |
| Mark Ingram | 4 | Miami Dolphins vs. New York Jets, November 27, 1994 |
| DeAngelo Williams (25) | 4 | Carolina Panthers vs. New York Giants, December 21, 2008 |
| Earl Campbell+ | 4 | Houston Oilers vs. Miami Dolphins, November 20, 1978 |
| Ahmad Rashad | 4 | Minnesota Vikings vs. San Francisco 49ers, September 2, 1979 |
| Larry Kinnebrew | 4 | Cincinnati Bengals vs. Houston Oilers, October 28, 1984 |
| Wesley Walker | 4 | New York Jets vs. Miami Dolphins, September 21, 1986 |
| John David Crow | 4 | St. Louis Cardinals vs. Philadelphia Eagles, December 16, 1962 |
| DeAngelo Williams (25) | 4 | Carolina Panthers vs. Green Bay Packers, November 30, 2008 |
| T.J. Duckett | 4 | Atlanta Falcons vs. Oakland Raiders, December 12, 2004 |
| Steven Jackson (23) | 4 | St. Louis Rams vs. Minnesota Vikings, December 31, 2006 |
| Art Powell | 4 | Oakland Raiders vs. Houston Oilers, December 22, 1963 |
| Jim Taylor+ | 4 | Green Bay Packers vs. Philadelphia Eagles, November 11, 1962 |
| Wilbert Montgomery | 4 | Philadelphia Eagles vs. Washington Redskins, October 7, 1979 |
| Chuck Foreman | 4 | Minnesota Vikings vs. Buffalo Bills, December 20, 1975 |
| MacArthur Lane | 4 | St. Louis Cardinals vs. Philadelphia Eagles, October 18, 1970 |
| Isaac Bruce | 4 | St. Louis Rams vs. San Francisco 49ers, October 10, 1999 |
| Lorenzo White | 4 | Houston Oilers vs. Cleveland Browns, December 9, 1990 |
| Lenny Moore+ | 4 | Baltimore Colts vs. Minnesota Vikings, October 1, 1961 |
| Priest Holmes | 4 | Kansas City Chiefs vs. Cleveland Browns, September 8, 2002 |
| Marshall Faulk+ | 4 | St. Louis Rams vs. Indianapolis Colts, December 30, 2001 |
| Terdell Middleton | 4 | Green Bay Packers vs. Seattle Seahawks, October 15, 1978 |
| Lenny Moore+ | 4 | Baltimore Colts vs. Los Angeles Rams, October 16, 1960 |
| Darren McFadden (23) | 4 | Oakland Raiders vs. Denver Broncos, October 24, 2010 |
| Jerry Butler | 4 | Buffalo Bills vs. New York Jets, September 23, 1979 |
| Jim Brown+ | 4 | Cleveland Browns vs. Philadelphia Eagles, November 19, 1961 |
| Marshall Faulk+ | 4 | St. Louis Rams vs. Seattle Seahawks, October 20, 2002 |
| Jimmie Giles | 4 | Tampa Bay Buccaneers vs. Miami Dolphins, October 20, 1985 |
| Larry Johnson | 4 | Kansas City Chiefs vs. Seattle Seahawks, October 29, 2006 |
| Jim Taylor+ | 4 | Green Bay Packers vs. Chicago Bears, November 4, 1962 |
| Harvey Williams | 4 | Oakland Raiders vs. San Diego Chargers, November 16, 1997 |
| Lydell Mitchell | 4 | Baltimore Colts vs. Buffalo Bills, October 12, 1975 |
| Dan Reeves | 4 | Dallas Cowboys vs. Atlanta Falcons, November 5, 1967 |
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