| 1. | Fred Taylor | 90 | Jacksonville Jaguars vs. Miami Dolphins, January 15, 2000 |
| 2. | Ray Rice (22) | 83 | Baltimore Ravens vs. New England Patriots, January 10, 2010 |
| 3. | Roger Craig | 80 | San Francisco 49ers vs. Minnesota Vikings, January 1, 1989 |
| Charlie Garner | 80 | Oakland Raiders vs. New York Jets, January 12, 2002 |
| 5. | Curtis Martin+ | 78 | New England Patriots vs. Pittsburgh Steelers, January 5, 1997 |
| 6. | Willie Parker | 75 | Pittsburgh Steelers vs. Seattle Seahawks, February 5, 2006 |
| 7. | Marcus Allen+ | 74 | Los Angeles Raiders vs. Washington Redskins, January 22, 1984 |
| Adrian Murrell | 74 | Arizona Cardinals vs. Dallas Cowboys, January 2, 1999 |
| 9. | Felix Jones (22) | 73 | Dallas Cowboys vs. Philadelphia Eagles, January 9, 2010 |
| 10. | Hugh McElhenny+ | 71 | San Francisco 49ers vs. Detroit Lions, December 22, 1957 |
| James Lofton+ | 71 | Green Bay Packers vs. Dallas Cowboys, January 16, 1983 |
| 12. | Tim Hightower | 70 | Arizona Cardinals vs. New Orleans Saints, January 16, 2010 |
| Elmer Angsman | 70 | Chicago Cardinals vs. Philadelphia Eagles, December 28, 1947 |
| 14. | Hewritt Dixon | 69 | Oakland Raiders vs. Houston Oilers, December 31, 1967 |
| 15. | Bill Osmanski | 68 | Chicago Bears vs. Washington Redskins, December 8, 1940 |
| Eddie George | 68 | Tennessee Titans vs. Indianapolis Colts, January 16, 2000 |
| 17. | Keith Lincoln | 67 | San Diego Chargers vs. Boston Patriots, January 5, 1964 |
| Marshawn Lynch (24) | 67 | Seattle Seahawks vs. New Orleans Saints, January 8, 2011 |
| Doak Walker+ | 67 | Detroit Lions vs. Cleveland Browns, December 28, 1952 |
| 20. | Earnest Byner | 66 | Cleveland Browns vs. Miami Dolphins, January 4, 1986 |
| Zack Crockett | 66 | Indianapolis Colts vs. San Diego Chargers, December 31, 1995 |
| 22. | Emmitt Smith+ | 65 | Dallas Cowboys vs. Minnesota Vikings, January 9, 2000 |
| Eric Dickerson+ | 65 | Los Angeles Rams vs. Washington Redskins, December 28, 1986 |
| 24. | Stephen Davis | 64 | Carolina Panthers vs. St. Louis Rams, January 10, 2004 |
| 25. | Marion Motley+ | 63 | Cleveland Browns vs. San Francisco 49ers, December 11, 1949 |
| 26. | Warrick Dunn | 62 | Atlanta Falcons vs. St. Louis Rams, January 15, 2005 |
| Chuck Foreman | 62 | Minnesota Vikings vs. Los Angeles Rams, December 26, 1976 |
| Natrone Means | 62 | Jacksonville Jaguars vs. Buffalo Bills, December 28, 1996 |
| Brian Westbrook | 62 | Philadelphia Eagles vs. New Orleans Saints, January 13, 2007 |
| Terrell Davis | 62 | Denver Broncos vs. Miami Dolphins, January 9, 1999 |
| 31. | Terrell Davis | 59 | Denver Broncos vs. Jacksonville Jaguars, December 27, 1997 |
| 32. | Tom Matte | 58 | Baltimore Colts vs. New York Jets, January 12, 1969 |
| Paul Lowe | 58 | San Diego Chargers vs. Boston Patriots, January 5, 1964 |
| Timmy Smith | 58 | Washington Redskins vs. Denver Broncos, January 31, 1988 |
| Tom Tracy | 58 | Detroit Lions vs. San Francisco 49ers, December 22, 1957 |
| Stephen Davis | 58 | Washington Redskins vs. Detroit Lions, January 8, 2000 |
| Thomas Sanders | 58 | Chicago Bears vs. Philadelphia Eagles, December 31, 1988 |
| 38. | Colin Kaepernick (25) | 56 | San Francisco 49ers vs. Green Bay Packers, January 12, 2013 |
| Billy Sims | 56 | Detroit Lions vs. San Francisco 49ers, December 31, 1983 |
| 40. | Eric Dickerson+ | 55 | Los Angeles Rams vs. Dallas Cowboys, January 4, 1986 |
| Wilbert Montgomery | 55 | Philadelphia Eagles vs. Dallas Cowboys, January 11, 1981 |
| 42. | Greg Bell | 54 | Los Angeles Rams vs. Philadelphia Eagles, December 31, 1989 |
| Marion Butts | 54 | San Diego Chargers vs. Kansas City Chiefs, January 2, 1993 |
| 44. | Tony Dorsett+ | 53 | Dallas Cowboys vs. Los Angeles Rams, January 7, 1979 |
| Joe Montana+ | 53 | San Francisco 49ers vs. New York Giants, December 29, 1984 |
| Shonn Greene (24) | 53 | New York Jets vs. San Diego Chargers, January 17, 2010 |
| 47. | Thomas Jones | 52 | Chicago Bears vs. Indianapolis Colts, February 4, 2007 |
| Lew Carpenter | 52 | Detroit Lions vs. Cleveland Browns, December 26, 1954 |
| 49. | Marion Motley+ | 51 | Cleveland Browns vs. New York Yankees, December 14, 1947 |
| Rodney Hampton | 51 | New York Giants vs. Minnesota Vikings, January 9, 1994 |
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