| 1. | Jamie Morris | 45 | Washington Redskins vs. Cincinnati Bengals, December 17, 1988 |
| 2. | Rudi Johnson | 43 | Cincinnati Bengals vs. Houston Texans, November 9, 2003 |
| James Wilder | 43 | Tampa Bay Buccaneers vs. Green Bay Packers, September 30, 1984 |
| Butch Woolfolk | 43 | New York Giants vs. Philadelphia Eagles, November 20, 1983 |
| 5. | James Wilder | 42 | Tampa Bay Buccaneers vs. Pittsburgh Steelers, October 30, 1983 |
| Terrell Davis | 42 | Denver Broncos vs. Buffalo Bills, October 26, 1997 |
| Ricky Williams | 42 | Miami Dolphins vs. Buffalo Bills, September 21, 2003 |
| 8. | Rodney Hampton | 41 | New York Giants vs. Los Angeles Rams, September 19, 1993 |
| Franco Harris+ | 41 | Pittsburgh Steelers vs. Cincinnati Bengals, October 17, 1976 |
| Gerald Riggs | 41 | Atlanta Falcons vs. Los Angeles Rams, November 17, 1985 |
| 11. | Barry Sanders+ | 40 | Detroit Lions vs. Dallas Cowboys, September 19, 1994 |
| Lydell Mitchell | 40 | Baltimore Colts vs. New York Jets, October 20, 1974 |
| Curtis Martin+ | 40 | New England Patriots vs. New York Jets, September 14, 1997 |
| Johnny Hector | 40 | New York Jets vs. New England Patriots, October 12, 1986 |
| Lamar Smith | 40 | Miami Dolphins vs. Indianapolis Colts, December 30, 2000 |
| Ricky Williams | 40 | New Orleans Saints vs. Cleveland Browns, October 31, 1999 |
| Adrian Murrell | 40 | New York Jets vs. Cincinnati Bengals, September 28, 1997 |
| Walter Payton+ | 40 | Chicago Bears vs. Minnesota Vikings, November 20, 1977 |
| Errict Rhett | 40 | Tampa Bay Buccaneers vs. Washington Redskins, December 4, 1994 |
| Shaun Alexander | 40 | Seattle Seahawks vs. Green Bay Packers, November 27, 2006 |
| 21. | O.J. Simpson+ | 39 | Buffalo Bills vs. Kansas City Chiefs, October 29, 1973 |
| LaDainian Tomlinson | 39 | San Diego Chargers vs. Oakland Raiders, October 20, 2002 |
| Corey Dillon | 39 | Cincinnati Bengals vs. Tennessee Oilers, December 4, 1997 |
| Ricky Bell | 39 | Tampa Bay Buccaneers vs. Kansas City Chiefs, December 16, 1979 |
| Jerome Bettis | 39 | Los Angeles Rams vs. Chicago Bears, January 2, 1994 |
| Jerome Harrison | 39 | Cleveland Browns vs. Oakland Raiders, December 27, 2009 |
| Terdell Middleton | 39 | Green Bay Packers vs. Minnesota Vikings, November 26, 1978 |
| Earl Campbell+ | 39 | Houston Oilers vs. Seattle Seahawks, October 11, 1981 |
| Gerald Riggs | 39 | Atlanta Falcons vs. New Orleans Saints, December 22, 1985 |
| Larry Johnson | 39 | Kansas City Chiefs vs. Seattle Seahawks, October 29, 2006 |
| Earnest Byner | 39 | Washington Redskins vs. New England Patriots, December 15, 1990 |
| Marion Butts | 39 | San Diego Chargers vs. Kansas City Chiefs, December 17, 1989 |
| Walter Payton+ | 39 | Chicago Bears vs. Buffalo Bills, October 7, 1979 |
| 34. | Lee Suggs | 38 | Cleveland Browns vs. Miami Dolphins, December 26, 2004 |
| Pete Johnson | 38 | Cincinnati Bengals vs. Pittsburgh Steelers, December 4, 1983 |
| Earl Campbell+ | 38 | Houston Oilers vs. Kansas City Chiefs, October 12, 1980 |
| Jim Nance | 38 | Boston Patriots vs. Oakland Raiders, October 30, 1966 |
| Clinton Portis | 38 | Denver Broncos vs. Cleveland Browns, December 14, 2003 |
| Stephen Davis | 38 | Washington Redskins vs. Arizona Cardinals, January 6, 2002 |
| Edgerrin James | 38 | Indianapolis Colts vs. Seattle Seahawks, October 15, 2000 |
| Joe Montgomery | 38 | New York Giants vs. New York Jets, December 5, 1999 |
| Christian Okoye | 38 | Kansas City Chiefs vs. Green Bay Packers, December 10, 1989 |
| Reuben Droughns | 38 | Denver Broncos vs. Oakland Raiders, October 17, 2004 |
| Ricky Williams | 38 | New Orleans Saints vs. Carolina Panthers, October 15, 2000 |
| Eric Dickerson+ | 38 | Los Angeles Rams vs. St. Louis Cardinals, September 7, 1986 |
| Ricky Bell | 38 | Tampa Bay Buccaneers vs. Philadelphia Eagles, December 29, 1979 |
| Cedric Benson (26) | 38 | Cincinnati Bengals vs. Cleveland Browns, December 21, 2008 |
| Curtis Martin+ | 38 | New York Jets vs. Arizona Cardinals, November 7, 1999 |
| John Riggins+ | 38 | Washington Redskins vs. Miami Dolphins, January 30, 1983 |
| Jamie Morris | 38 | Washington Redskins vs. Philadelphia Eagles, November 12, 1989 |
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