| 1. | Milt Plum | 22.0 | Cleveland Browns vs. Pittsburgh Steelers, October 2, 1960 |
| 2. | Craig Morton | 20.5 | Dallas Cowboys vs. Houston Oilers, December 20, 1970 |
| 3. | Earl Morrall | 19.7 | New York Giants vs. Philadelphia Eagles, October 17, 1965 |
| 4. | Tony Banks | 19.0 | St. Louis Rams vs. Atlanta Falcons, December 15, 1996 |
| 5. | Len Dawson+ | 18.5 | Kansas City Chiefs vs. Denver Broncos, September 7, 1963 |
| Johnny Unitas+ | 18.5 | Baltimore Colts vs. Atlanta Falcons, November 12, 1967 |
| 7. | James Harris | 18.4 | Los Angeles Rams vs. San Francisco 49ers, October 20, 1974 |
| 8. | Len Dawson+ | 18.3 | Kansas City Chiefs vs. Miami Dolphins, November 13, 1966 |
| 9. | Lynn Dickey | 17.8 | Green Bay Packers vs. Tampa Bay Buccaneers, October 2, 1983 |
| John Hadl | 17.8 | San Diego Chargers vs. Denver Broncos, October 20, 1968 |
| 11. | Joe Namath+ | 17.7 | New York Jets vs. Baltimore Colts, September 24, 1972 |
| Kurt Warner | 17.7 | St. Louis Rams vs. Atlanta Falcons, September 24, 2000 |
| 13. | Steve Grogan | 17.5 | New England Patriots vs. New York Jets, September 9, 1979 |
| 14. | Chris Chandler | 17.4 | Atlanta Falcons vs. Carolina Panthers, September 23, 2001 |
| 15. | Craig Morton | 17.1 | Denver Broncos vs. San Diego Chargers, September 27, 1981 |
| 16. | John Brodie | 16.9 | San Francisco 49ers vs. Chicago Bears, November 19, 1961 |
| Johnny Unitas+ | 16.9 | Baltimore Colts vs. Dallas Cowboys, October 30, 1960 |
| 18. | Ken Anderson | 16.8 | Cincinnati Bengals vs. Houston Oilers, October 29, 1978 |
| 19. | Bob Griese+ | 16.6 | Miami Dolphins vs. Pittsburgh Steelers, November 14, 1971 |
| Roger Staubach+ | 16.6 | Dallas Cowboys vs. New York Giants, December 12, 1971 |
| 21. | Charley Johnson | 16.5 | Denver Broncos vs. Kansas City Chiefs, September 21, 1975 |
| Fran Tarkenton+ | 16.5 | New York Giants vs. Washington Redskins, September 29, 1968 |
| 23. | Jim Kelly+ | 16.4 | Buffalo Bills vs. New England Patriots, October 1, 1989 |
| Warren Rabb | 16.4 | Buffalo Bills vs. Denver Broncos, October 28, 1962 |
| 25. | Charley Johnson | 16.3 | St. Louis Cardinals vs. Cleveland Browns, September 26, 1965 |
| Sonny Jurgensen+ | 16.3 | Philadelphia Eagles vs. Dallas Cowboys, November 25, 1962 |
| Marc Wilson | 16.3 | Los Angeles Raiders vs. Seattle Seahawks, October 7, 1984 |
| 28. | Len Dawson+ | 16.2 | Dallas Texans vs. Denver Broncos, November 18, 1962 |
| Daryle Lamonica | 16.2 | Oakland Raiders vs. Houston Oilers, December 21, 1969 |
| 30. | Drew Brees (30) | 16.1 | New Orleans Saints vs. New England Patriots, November 30, 2009 |
| Billy Joe Tolliver | 16.1 | New Orleans Saints vs. San Francisco 49ers, November 14, 1999 |
| Matt Schaub (30) | 16.1 | Houston Texans vs. Tampa Bay Buccaneers, November 13, 2011 |
| 33. | Craig Morton | 16.0 | Dallas Cowboys vs. Pittsburgh Steelers, October 22, 1967 |
| Bart Starr+ | 16.0 | Green Bay Packers vs. Cleveland Browns, October 15, 1961 |
| 35. | Ed Brown | 15.9 | Chicago Bears vs. Los Angeles Rams, October 9, 1960 |
| Dan Fouts+ | 15.9 | San Diego Chargers vs. Cleveland Browns, November 3, 1974 |
| Warren Moon+ | 15.9 | Houston Oilers vs. Miami Dolphins, September 8, 1985 |
| 38. | Steve DeBerg | 15.8 | Kansas City Chiefs vs. New England Patriots, December 2, 1990 |
| Craig Morton | 15.8 | Dallas Cowboys vs. Buffalo Bills, September 19, 1971 |
| 40. | Jim McMahon | 15.7 | Chicago Bears vs. Minnesota Vikings, September 19, 1985 |
| Craig Morton | 15.7 | Denver Broncos vs. Detroit Lions, October 11, 1981 |
| Johnny Unitas+ | 15.7 | Baltimore Colts vs. Detroit Lions, November 10, 1963 |
| 43. | Steve McNair | 15.6 | Tennessee Titans vs. Houston Texans, October 12, 2003 |
| Chad Pennington | 15.6 | New York Jets vs. Indianapolis Colts, November 16, 2003 |
| Jay Schroeder | 15.6 | Los Angeles Raiders vs. Minnesota Vikings, December 22, 1990 |
| Fran Tarkenton+ | 15.6 | New York Giants vs. St. Louis Cardinals, October 25, 1970 |
| Johnny Unitas+ | 15.6 | Baltimore Colts vs. Minnesota Vikings, December 8, 1963 |
| 48. | Len Dawson+ | 15.5 | Kansas City Chiefs vs. Denver Broncos, November 21, 1971 |
| Jeff Hostetler | 15.5 | Los Angeles Raiders vs. Denver Broncos, January 9, 1994 |
| Mike Tomczak | 15.5 | Pittsburgh Steelers vs. San Diego Chargers, December 24, 1994 |
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