| Rank | Player | Int% | Year | Teams |
|---|---|---|---|---|
| 1. | Y.A. Tittle+ (37) | 17.2% | 1963 | NYG |
| 2. | Jay Schroeder (29) | 16.1% | 1990 | RAI |
| 3. | Jake Delhomme (33) | 14.7% | 2008 | CAR |
| 4. | Scott Mitchell (27) | 13.8% | 1995 | DET |
| Doug Williams (26) | 13.8% | 1981 | TAM | |
| 6. | Gary Danielson (32) | 13.2% | 1983 | DET |
| 7. | Tommy Kramer (25) | 12.8% | 1980 | MIN |
| 8. | George Blanda+ (34) | 12.5% | 1961 | HOU |
| Jack Kemp (26) | 12.5% | 1961 | SDG | |
| 10. | Brett Favre (35) | 12.1% | 2004 | GNB |
| 11. | Len Dawson+ (33) | 11.1% | 1968 | KAN |
| Brad Johnson (33) | 11.1% | 2001 | TAM | |
| 13. | George Blanda+ (35) | 10.9% | 1962 | HOU |
| 14. | Doug Williams (27) | 10.7% | 1982 | TAM |
| Billy Kilmer (33) | 10.7% | 1972 | WAS | |
| 16. | Dan Fouts+ (28) | 10.6% | 1979 | SDG |
| 17. | Chad Pennington (32) | 10.5% | 2008 | MIA |
| 18. | Joe Ferguson (30) | 10.3% | 1980 | BUF |
| Jim Kelly+ (35) | 10.3% | 1995 | BUF | |
| Jim McMahon (28) | 10.3% | 1987 | CHI | |
| 21. | Joe Flacco (23) | 10.0% | 2008 | BAL |
| John Brodie (36) | 10.0% | 1971 | SFO | |
| Vince Ferragamo (26) | 10.0% | 1980 | RAM | |
| 24. | Ken O'Brien (31) | 9.7% | 1991 | NYJ |
| 25. | Brett Favre (32) | 9.6% | 2001 | GNB |