| Rank | Player | Int% | Years | Teams |
|---|---|---|---|---|
| 1. | Alex Smith (27) | 0.0% | 2005-2012 | sfo |
| Jay Cutler (28) | 0.0% | 2006-2012 | chi | |
| 3. | Drew Brees (32) | 1.0% | 2001-2012 | 2TM |
| 4. | Tony Romo (31) | 1.5% | 2004-2012 | dal |
| Eli Manning (30) | 1.5% | 2004-2012 | nyg | |
| 6. | Andrew Luck (22) | 1.9% | 2012 | clt |
| Aaron Rodgers (28) | 1.9% | 2005-2012 | gnb | |
| 8. | Mark Sanchez (25) | 2.1% | 2009-2012 | nyj |
| 9. | Matt Schaub (30) | 2.2% | 2004-2012 | htx |
| 10. | Matt Hasselbeck (36) | 2.4% | 1999-2012 | sea |
| 11. | Joe Flacco (26) | 2.6% | 2008-2012 | rav |
| 12. | Russell Wilson (23) | 2.8% | 2012 | sea |
| Carson Palmer (32) | 2.8% | 2004-2012 | cin | |
| 14. | Tarvaris Jackson (28) | 2.9% | 2006-2012 | min |
| Tom Brady (34) | 2.9% | 2000-2012 | nwe | |
| 16. | Peyton Manning (35) | 3.0% | 1998-2012 | 2TM |
| 17. | Byron Leftwich (31) | 3.2% | 2003-2012 | jax |
| 18. | Ben Roethlisberger (29) | 3.3% | 2004-2012 | pit |
| Joe Webb (25) | 3.3% | 2010-2012 | min | |
| 20. | Colin Kaepernick (24) | 3.4% | 2011-2012 | sfo |
| 21. | Matt Ryan (26) | 3.7% | 2008-2012 | atl |
| 22. | Philip Rivers (30) | 3.8% | 2004-2012 | sdg |
| 23. | Michael Vick (31) | 4.1% | 2001-2012 | 2TM |
| 24. | Matthew Stafford (23) | 4.7% | 2009-2012 | det |
| 25. | Andy Dalton (24) | 5.6% | 2011-2012 | cin |
| 26. | T.J. Yates (24) | 8.6% | 2011-2012 | htx |