| Rank | Player | AY/A | Years | Teams |
|---|---|---|---|---|
| 1. | Jay Cutler (28) | 11.21 | 2006-2012 | chi |
| 2. | Kelly Holcomb | 10.33 | 1997-2007 | cle |
| 3. | Don Strock | 10.19 | 1974-1988 | mia |
| 4. | Russell Wilson (23) | 9.47 | 2012 | sea |
| 5. | Bart Starr+ | 9.39 | 1956-1971 | gnb |
| 6. | Colin Kaepernick (24) | 9.07 | 2011-2012 | sfo |
| 7. | Alex Smith (27) | 8.75 | 2005-2012 | sfo |
| 8. | Kurt Warner | 8.67 | 1998-2009 | 2TM |
| 9. | Dan Pastorini | 8.49 | 1971-1983 | oti |
| 10. | Aaron Rodgers (28) | 8.38 | 2005-2012 | gnb |
| 11. | David Garrard | 8.27 | 2002-2010 | jax |
| Drew Brees (32) | 8.27 | 2001-2012 | 2TM | |
| 13. | Matthew Stafford (23) | 8.14 | 2009-2012 | det |
| Paul McDonald | 8.14 | 1980-1986 | cle | |
| 15. | Steve DeBerg | 8.13 | 1978-1998 | kan |
| 16. | Joe Montana+ | 7.95 | 1979-1994 | 2TM |
| 17. | Steve Bartkowski | 7.82 | 1975-1986 | atl |
| 18. | Trent Green | 7.73 | 1997-2008 | kan |
| 19. | Erik Kramer | 7.57 | 1987-1999 | 2TM |
| 20. | Jeff Hostetler | 7.56 | 1985-1997 | nyg |
| 21. | Mark Malone | 7.52 | 1980-1989 | pit |
| 22. | Jack Trudeau | 7.45 | 1986-1995 | clt |
| 23. | Jeff George | 7.44 | 1990-2001 | 2TM |
| 24. | Ken Anderson | 7.38 | 1971-1986 | cin |
| 25. | Eli Manning (30) | 7.27 | 2004-2012 | nyg |
| 26. | Mark Sanchez (25) | 7.12 | 2009-2012 | nyj |
| 27. | Aaron Brooks | 7.09 | 2000-2006 | nor |
| 28. | Marc Bulger | 7.07 | 2002-2009 | ram |
| 29. | Scott Brunner | 7.03 | 1980-1985 | nyg |
| 30. | Joe Flacco (26) | 7.00 | 2008-2012 | rav |
| 31. | Rich Gannon | 6.99 | 1987-2004 | rai |
| 32. | Ben Roethlisberger (29) | 6.95 | 2004-2012 | pit |
| 33. | Daryle Lamonica | 6.94 | 1963-1974 | rai |
| 34. | Bernie Kosar | 6.93 | 1985-1996 | cle |
| 35. | Frank Reich | 6.89 | 1985-1998 | buf |
| 36. | Don Meredith | 6.87 | 1960-1968 | dal |
| 37. | Babe Parilli | 6.86 | 1952-1969 | nwe |
| 38. | Danny Kanell | 6.84 | 1996-2003 | nyg |
| 39. | Daunte Culpepper | 6.83 | 1999-2009 | min |
| 40. | John Elway+ | 6.81 | 1983-1998 | den |
| Terry Bradshaw+ | 6.81 | 1970-1983 | pit | |
| 42. | Tommy Maddox | 6.72 | 1992-2005 | pit |
| 43. | Ken Stabler | 6.69 | 1970-1984 | rai |
| 44. | Jake Delhomme | 6.65 | 1999-2011 | car |
| 45. | Warren Moon+ | 6.58 | 1984-2000 | 2TM |
| 46. | Neil Lomax | 6.57 | 1981-1988 | crd |
| 47. | Peyton Manning (35) | 6.56 | 1998-2012 | 2TM |
| 48. | Wade Wilson | 6.55 | 1981-1998 | min |
| 49. | Troy Aikman+ | 6.50 | 1989-2000 | dal |
| 50. | Matt Hasselbeck (36) | 6.48 | 1999-2012 | sea |