| 1. | Glyn Milburn | 404 | Denver Broncos vs. Seattle Seahawks, December 10, 1995 |
| 2. | Billy Cannon | 373 | Houston Oilers vs. New York Titans, December 10, 1961 |
| 3. | Adrian Peterson (22) | 361 | Minnesota Vikings vs. Chicago Bears, October 14, 2007 |
| 4. | Michael Lewis | 356 | New Orleans Saints vs. Washington Redskins, October 13, 2002 |
| 5. | Ed Podolak | 350 | Kansas City Chiefs vs. Miami Dolphins, December 25, 1971 |
| 6. | Tyrone Hughes | 347 | New Orleans Saints vs. Los Angeles Rams, October 23, 1994 |
| 7. | Lionel James | 345 | San Diego Chargers vs. Los Angeles Raiders, November 10, 1985 |
| 8. | Timmy Brown | 341 | Philadelphia Eagles vs. St. Louis Cardinals, December 16, 1962 |
| 9. | Gale Sayers+ | 339 | Chicago Bears vs. Minnesota Vikings, December 18, 1966 |
| 10. | Gale Sayers+ | 336 | Chicago Bears vs. San Francisco 49ers, December 12, 1965 |
| Flipper Anderson | 336 | Los Angeles Rams vs. New Orleans Saints, November 26, 1989 |
| 12. | Jason Tucker | 331 | Dallas Cowboys vs. New Orleans Saints, December 24, 1999 |
| 13. | Keith Lincoln | 329 | San Diego Chargers vs. Boston Patriots, January 5, 1964 |
| Jacoby Ford | 329 | Oakland Raiders vs. Miami Dolphins, November 28, 2010 |
| Jerry LeVias | 329 | Houston Oilers vs. New York Jets, December 6, 1969 |
| 16. | Darren Sproles (25) | 328 | San Diego Chargers vs. Indianapolis Colts, January 3, 2009 |
| 17. | David Wilson (21) | 327 | New York Giants vs. New Orleans Saints, December 9, 2012 |
| 18. | Steve Breaston (25) | 324 | Arizona Cardinals vs. New York Jets, September 28, 2008 |
| 19. | John Taylor | 321 | San Francisco 49ers vs. Los Angeles Rams, December 11, 1989 |
| 20. | Gary Ballman | 320 | Pittsburgh Steelers vs. Washington Redskins, November 17, 1963 |
| 21. | Darren Sproles (25) | 317 | San Diego Chargers vs. Denver Broncos, September 14, 2008 |
| Devin Hester (25) | 317 | Chicago Bears vs. Detroit Lions, September 30, 2007 |
| 23. | Lionel James | 316 | San Diego Chargers vs. Cincinnati Bengals, September 22, 1985 |
| Josh Cribbs (26) | 316 | Cleveland Browns vs. Kansas City Chiefs, December 20, 2009 |
| 25. | Adrian Peterson (22) | 315 | Minnesota Vikings vs. San Diego Chargers, November 4, 2007 |
| 26. | Travis Williams | 314 | Green Bay Packers vs. Pittsburgh Steelers, November 2, 1969 |
| 27. | Jim Brown+ | 313 | Cleveland Browns vs. Philadelphia Eagles, November 19, 1961 |
| Steve Smith (23) | 313 | Carolina Panthers vs. Cincinnati Bengals, December 8, 2002 |
| 29. | Josh Cribbs (24) | 309 | Cleveland Browns vs. Baltimore Ravens, November 18, 2007 |
| Stephone Paige | 309 | Kansas City Chiefs vs. San Diego Chargers, December 22, 1985 |
| 31. | Jermaine Lewis | 308 | Baltimore Ravens vs. Seattle Seahawks, December 7, 1997 |
| 32. | Kevin Williams | 307 | Dallas Cowboys vs. Arizona Cardinals, December 25, 1995 |
| Priest Holmes | 307 | Kansas City Chiefs vs. Seattle Seahawks, November 24, 2002 |
| 34. | Tim Brown | 306 | Los Angeles Raiders vs. Seattle Seahawks, November 28, 1988 |
| Jacoby Ford | 306 | Oakland Raiders vs. Kansas City Chiefs, November 7, 2010 |
| 36. | Greg Pruitt | 304 | Cleveland Browns vs. Cincinnati Bengals, November 23, 1975 |
| Jonathan Carter | 304 | New York Jets vs. Indianapolis Colts, November 16, 2003 |
| 38. | O.J. Simpson+ | 303 | Buffalo Bills vs. New York Jets, October 4, 1970 |
| Maurice Jones-Drew (21) | 303 | Jacksonville Jaguars vs. Indianapolis Colts, December 10, 2006 |
| Domenik Hixon (25) | 303 | New York Giants vs. New Orleans Saints, October 18, 2009 |
| 41. | Mercury Morris | 302 | Miami Dolphins vs. Baltimore Colts, November 1, 1970 |
| Derrick Mason | 302 | Tennessee Titans vs. Buffalo Bills, December 14, 2003 |
| 43. | Walter Payton+ | 300 | Chicago Bears vs. New Orleans Saints, December 21, 1975 |
| 44. | Leroy Kelly+ | 299 | Cleveland Browns vs. New York Giants, December 4, 1966 |
| Eddie Payton | 299 | Detroit Lions vs. Minnesota Vikings, December 17, 1977 |
| Jerry Rice+ | 299 | San Francisco 49ers vs. Minnesota Vikings, December 18, 1995 |
| Ted Ginn Jr. (24) | 299 | Miami Dolphins vs. New York Jets, November 1, 2009 |
| 48. | Jerome Harrison | 298 | Cleveland Browns vs. Kansas City Chiefs, December 20, 2009 |
| 49. | Wes Welker (24) | 297 | Miami Dolphins vs. Tampa Bay Buccaneers, October 16, 2005 |
| Gale Sayers+ | 297 | Chicago Bears vs. Minnesota Vikings, October 17, 1965 |
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