| 1. | Michael Lewis | 44.5 | New Orleans Saints vs. Washington Redskins, October 13, 2002 |
| 2. | Jonathan Carter | 43.4 | New York Jets vs. Indianapolis Colts, November 16, 2003 |
| 3. | Gary Ballman | 40.0 | Pittsburgh Steelers vs. Washington Redskins, September 25, 1966 |
| 4. | Ron J. Brown | 38.7 | Los Angeles Rams vs. Green Bay Packers, November 24, 1985 |
| 5. | Desmond Howard | 38.6 | Detroit Lions vs. Cincinnati Bengals, October 28, 2001 |
| Stephone Paige | 38.6 | Kansas City Chiefs vs. San Diego Chargers, December 22, 1985 |
| 7. | Jerome Mathis | 38.0 | Houston Texans vs. Indianapolis Colts, October 23, 2005 |
| Jerome Mathis | 38.0 | Houston Texans vs. Kansas City Chiefs, November 20, 2005 |
| 9. | Tony Smith | 37.3 | Atlanta Falcons vs. Pittsburgh Steelers, September 27, 1993 |
| 10. | Anthony Allen | 36.4 | Washington Redskins vs. St. Louis Cardinals, October 4, 1987 |
| 11. | Brian Mitchell | 36.3 | Washington Redskins vs. Denver Broncos, September 17, 1995 |
| Noland Smith | 36.3 | Kansas City Chiefs vs. San Diego Chargers, October 15, 1967 |
| Jacoby Jones (28) | 36.3 | Baltimore Ravens vs. San Francisco 49ers, February 3, 2013 |
| 14. | Josh Scobey | 36.0 | Arizona Cardinals vs. St. Louis Rams, September 28, 2003 |
| Freddie Solomon | 36.0 | Miami Dolphins vs. Buffalo Bills, December 5, 1976 |
| 16. | Bob Hayes+ | 35.6 | Dallas Cowboys vs. Cleveland Browns, December 24, 1967 |
| 17. | Rick Upchurch | 35.5 | Denver Broncos vs. Kansas City Chiefs, September 21, 1975 |
| 18. | Chad Morton | 35.4 | New York Jets vs. Buffalo Bills, September 8, 2002 |
| 19. | Steve Smith (23) | 34.8 | Carolina Panthers vs. Cincinnati Bengals, December 8, 2002 |
| Johnny Knox | 34.8 | Chicago Bears vs. Oakland Raiders, November 27, 2011 |
| 21. | Tyrone Hughes | 34.7 | New Orleans Saints vs. Los Angeles Rams, October 23, 1994 |
| 22. | Harold Jackson | 34.0 | Los Angeles Rams vs. Dallas Cowboys, October 14, 1973 |
| 23. | Tommy McDonald+ | 33.9 | Philadelphia Eagles vs. New York Giants, December 10, 1961 |
| 24. | Justin Blackmon (22) | 33.7 | Jacksonville Jaguars vs. Houston Texans, November 18, 2012 |
| 25. | Desmond Howard | 33.6 | Detroit Lions vs. Tampa Bay Buccaneers, September 17, 2000 |
| 26. | Terry Fair | 33.4 | Detroit Lions vs. Green Bay Packers, September 6, 1998 |
| Tony Horne | 33.4 | St. Louis Rams vs. Kansas City Chiefs, October 22, 2000 |
| 28. | Josh Cribbs (29) | 33.3 | Cleveland Browns vs. New York Giants, October 7, 2012 |
| 29. | Allen Rossum | 33.1 | Atlanta Falcons vs. St. Louis Rams, January 15, 2005 |
| 30. | Jason Tucker | 33.0 | Dallas Cowboys vs. New York Giants, October 15, 2000 |
| 31. | Mel J. Gray | 32.9 | Houston Oilers vs. Cincinnati Bengals, October 6, 1996 |
| 32. | DeSean Jackson (23) | 32.6 | Philadelphia Eagles vs. New York Giants, December 13, 2009 |
| 33. | Bobby Mitchell+ | 32.4 | Washington Redskins vs. Dallas Cowboys, September 16, 1962 |
| Willie Ponder | 32.4 | New York Giants vs. Pittsburgh Steelers, December 18, 2004 |
| 35. | Walter Roberts | 32.3 | New Orleans Saints vs. Philadelphia Eagles, November 19, 1967 |
| Wes Welker (23) | 32.3 | Miami Dolphins vs. New England Patriots, December 20, 2004 |
| 37. | Brian Mitchell | 32.2 | Philadelphia Eagles vs. Atlanta Falcons, October 1, 2000 |
| 38. | Kenny Britt (22) | 32.1 | Tennessee Titans vs. Philadelphia Eagles, October 24, 2010 |
| Eddie Drummond | 32.1 | Detroit Lions vs. Jacksonville Jaguars, November 14, 2004 |
| 40. | Roell Preston | 32.0 | Green Bay Packers vs. Minnesota Vikings, October 5, 1998 |
| 41. | Dominic Rhodes | 31.9 | Indianapolis Colts vs. San Diego Chargers, December 26, 2004 |
| Walter Stanley | 31.9 | Green Bay Packers vs. Detroit Lions, November 27, 1986 |
| 43. | Ronney Jenkins | 31.7 | San Diego Chargers vs. New Orleans Saints, September 10, 2000 |
| 44. | J.J. Arrington | 31.6 | Arizona Cardinals vs. Minnesota Vikings, November 26, 2006 |
| Tyrone Hughes | 31.6 | New Orleans Saints vs. Philadelphia Eagles, December 26, 1993 |
| Nate Lewis | 31.6 | Chicago Bears vs. Minnesota Vikings, December 1, 1994 |
| Lance Moore (27) | 31.6 | New Orleans Saints vs. Atlanta Falcons, September 26, 2010 |
| Derrick Witherspoon | 31.6 | Philadelphia Eagles vs. Arizona Cardinals, November 24, 1996 |
| 49. | Elbert Dubenion | 31.4 | Buffalo Bills vs. Boston Patriots, December 28, 1963 |
| Frank Jackson | 31.4 | Kansas City Chiefs vs. Denver Broncos, December 19, 1965 |
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